|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
|
21499250 |
2011 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
|
17603485 |
2007 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
|
17603485 |
2007 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Two susceptibility loci identified for prostate cancer aggressiveness.
|
25939597 |
2015 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer.
|
18696045 |
2008 |
|
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Twelve genes (BAG1, DDR1, ERBB4, ESR1, HSPD1, IGFBP2, IGFBP5, NR4A1, PAWR, PIK3CG, RAP2A, and TPD52) were found to be associated with both HNF1b and prostate cancer risk.
|
23661456 |
2013 |
|
Prostate carcinoma
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
This tumor-suppressor activity is lost when HNF1B is silenced by promoter methylation in the progression to PC.
|
27732966 |
2016 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk.
|
21576123 |
2011 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the HNF1B variants are directly associated with both diabetes and prostate cancer, that diabetes does not mediate these gene variant-prostate cancer relationships, and the relationship between these diseases is not mediated through these gene variants.
|
19998368 |
2010 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis.
|
20203524 |
2010 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The examined HNF1B variants have a highly specific effect on prostate cancer risk with no apparent association with any of the other studied cancer types.
|
20526366 |
2010 |
|
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Some associations appear to be ancestry specific, such as HNF1B, which is associated with prostate cancer in European Americans and Latinos but not in African-Americans.
|
21459759 |
2011 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies.
|
26214421 |
2015 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
|
26443449 |
2015 |
|
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we find that higher HNF1B expression strongly predicts better prognosis of prostate cancer, alone or together with lower EZH2 expression.
|
31636385 |
2020 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
|
19767753 |
2009 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.
|
23464444 |
2012 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.
|
30410027 |
2018 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
|
20676098 |
2010 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association scan for variants associated with early-onset prostate cancer.
|
24740154 |
2014 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21.
|
27262462 |
2016 |
|
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of HNF1B and ECI2 proteins were validated by immunohistochemistry and western blotting at different stages of prostate cancer development.
|
30655870 |
2019 |
|
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
|
18758462 |
2008 |